HHS to US Senate?

I found this article to be interesting because Kathleen Sebelius was a popular governor of a very conservative state before becoming HHS Secretary. She recently stepped down and has said she is comtemplating a return to Washington via US Senate. Since she was the most used face of the ACA, I do not think that she can count on the wide array of support she has enjoyed in years past. She has also been gone from the state for a number of years and will have to re-introduce herself to many of the voters. Ultimately, I just don't see her mounting a campaign with the ACA so fresh in everyone's mind.